Endocrine Abstracts

Objective: For women with polycystic ovary syndrome (PCOS) weight gain and obesity exacerbate insulin resistance and increase the risk of type 2 diabetes and cardiometabolic diseases. The PCOS Phenotype in Unselected Populations (P-PUP) study includes individual participant data (IPD) from eleven well characterised, multiethnic and unselected populations globally. The aim of this study was to assess risk of obesity in women with and without PCOS according to ethnicity and age....

Introduction: Although lifestyle measures and medical therapy are the cornerstone of type 2 diabetes (T2DM) management, achieving optimal glycemic control in T2DM patients with obesity remains challenging. There is strong and consistent evidence that bariatric surgery (BS) is an effective strategy to improve glycemia in diabetic patients and often leads to remission of T2DM in patients with obesity. The majority of the published literature supporting T2DM remission after BS ha...

Background: The interplay of genetic, immune and environmental factors strongly contributes to the development of autoimmune thyroid disease (AITD) in the form of Graves’ disease (GD) and Hashimoto thyroiditis (HT). One of the most studied exogenous factors in the pathogenesis of AITD is selenium, which in the form of selenoproteins strengthens the antioxidative defence system of thyroid cells against superoxide production. Furthermore, it modulates inflammatory cytokine ...

Introduction: Graves’ disease (GD) can negatively affect the quality of life. Research on GD in childhood, accounting for 1-5% of cases, has so far predominantly focused on treatment results. There is limited knowledge about association with other diseases and long-term psychosocial effects.Aims: We aimed to compare disease burden and psychosocial outcomes between childhood/young adult GD patients and unexposed population controls.<p class="abst...

Introduction: Ectopic adrenal tissue (EAT) occurs in less than 1% of adults, more commonly in males. It may be found anywhere along the path of embryogenic migration, usually in the kidney and retroperitoneal fat. We report a case of EAT in the fallopian tube, a particularly rare localization.Case: We present a 57-year-old female with a known medical history of nephrolithiasis and previous ectopic pregnancies. The patient was submitted to a laparoscopic ...

Background: Hypophosphatemic rickets are disabling conditions that negatively impact physical functioning, activities of daily living, mental health, social life, and leisure activities. The most common cause of Hypophosphatemic rickets is genetic factors, such as X-linked hypophosphatemia. The evaluation of the scientific application of familial hypophosphatemic rickets aids in understanding the research landscape, identifying opportunities for improvement, and promoting sign...

Introduction: National Institute of Health and Care Excellence (NICE) recommends screening for emotional wellbeing as part of consultations for polycystic ovary syndrome (PCOS).Aim: We evaluated several dimensions of emotional wellbeing in people attending PCOS consultation in the UK and India.Methods: All people attending reproductive endocrine clinic for PCOS at three centres: Queen Elizabeth Hospital Birmingham, UK; Apollo Hospi...

Aim: To study differences in various aspects of emotional wellbeing among women with PCOS living in the UK and India.Methods: Women with PCOS were invited to complete an online survey between September and October 2020 in the UK and May and June 2021 in India. The survey included Hospital Anxiety and Depression Scale (HADS; score ≥11 cases of anxiety and depression, respectively), Body Image Concern Inventory (BICI; score ≥72 suggestive of bo...

Introduction: Monogenic forms of diabetes that develop with autosomal dominant inheritance are classically aggregated in the maturity-onset diabetes of the young (MODY) categories. Despite increasing awareness, its true prevalence remains largely underestimated.Aim: o evaluate the clinical and molecular characteristics of patients with MODY.Methodology: This single-center retrospective cohort study enrolled patients with positive g...

Background: Subtle symptoms such as fatigue, weight gain and depression are commonly present for years in patients with pituitary adenoma (PA) before the diagnosis is made. A delayed diagnosis with risk of increased morbidity and mortality may be due to differences between patient-reported symptoms and symptoms reported in the patient’s medical record.Aim: To estimate diagnostic delay and investigate the concordance between patient-reported symptoms...